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SHP2 inhibitors may be of dual benefit here, since, notably, a recent study reported that allosteric SHP2 inhibitors could additionally inhibit autophagy as an off-target effect due to their accumulation in lysosomes

The cytosolic glutathione pool influences the Mia40 redox state The possibility of reversible disulphide bond formation in the IMS is supported by the effects of varying E GSH [IMS] on the redox state of Mia40 (Figure 9B)

doi: 10.1002/mnfr.201100222, 77

Proteomics 10, 129

Rat studies on Achilles tendon transection, patellar ligament rupture, and rotator cuff injuries consistently show accelerated healing timelines, improved tensile strength, and superior histological organization in BPC-157-treated groups versus untreated controls

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